A cognitive assessment strategy that is not limited to examining a set of summary test scores may be more helpful for early detection of emergent illness such as Alzheimer’s disease (AD) and may permit a better understanding of cognitive functions and dysfunctions in those with AD and other dementia disorders. A revisit of the work already undertaken by Kaplan and colleagues using the Boston Process-Approach provides a solid basis for identifying new opportunities to capture data on neurocognitive processes, test-taking strategies (...) and response styles. Thus, this critical review will combine traditional process-based assessment strategies with support provided or offered by newer technologies that have the potential to add value to data collection and interpretation. There is now considerable interest in neuropsychological test administration using computer/digital technology, both in research and in clinical settings. To add value, any computerized version of an existing cognitive test should respect the administration procedure for which normative data were obtained, should be time-saving in terms of scoring and interpretation, and should, we argue, facilitate gathering information about the processes and strategies followed in test completion. This article will offer an overview of the steps needed when implementing computerization of neuropsychological tests using a Process-Based Approach (PBA) to these technology-based adaptations and will discuss further developments in this area by linking it to future technological developments that may be possible in the area of neuropsychological assessment. Additionally, an overview of neuropsychological tests that may benefit from computerization will be presented, together with suggestions on the specific processes, strategies and features that may be captured with the aid of such computerization. Finally, hypotheses on how virtual reality could be an asset for the future of the PBA to neuropsychological assessment will also be discussed. (shrink)

Current accounts suggest that self-referential thought serves a pivotal function in the human ability to simulate the future during mind-wandering. Using experience sampling, this hypothesis was tested in two studies that explored the extent to which self-reflection impacts both retrospection and prospection during mind-wandering. Study 1 demonstrated that a brief period of self-reflection yielded a prospective bias during mind-wandering such that participants’ engaged more frequently in spontaneous future than past thought. In Study 2, individual differences in the strength of self-referential (...) thought — as indexed by the memorial advantage for self rather than other-encoded items — was shown to vary with future thinking during mind-wandering. Together these results confirm that self-reflection is a core component of future thinking during mind-wandering and provide novel evidence that a key function of the autobiographical memory system may be to mentally simulate events in the future. (shrink)

The essays in this book discuss the originally proposed Baldwin effect, how it was modified over time, and its possible contribution to contemporary empirical...

A collection of personal narratives and essays, Living Professionalism is designed to help medical students and residents understand and internalize various aspects of professionalism. These essays are meant for personal reflection and above all, for thoughtful discussion with mentors, with peers, with others throughout the health care provider community who care about acting professionally.

Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

Sometimes it feels as though we can control our minds. We catch ourselves looking out the window when we should be paying attention to someone talking, for example, and we purposefully return our attention to the conversation. Or we wrest our minds away from the bothersome thought of an upcoming dental appointment to focus on anything we can find that makes us less nervous. Control attempts such as these can meet with success, leaving us feeling the masters of our consciousness. (...) Yet at other times.. (shrink)

A month ago, I bought an iPhone. The iPhone has already taken over some of the central functions of my brain. It has replaced part of my memory, storing phone numbers and addresses that I once would have taxed my brain with. It harbors my desires: I call up a memo with the names of my favorite dishes when I need to order at a local restaurant. I use it to calculate, when I need to figure out bills and tips. (...) It is a tremendous resource in an argument, with Google ever present to help settle disputes. I make plans with it, using its calendar to help determine what I can and can’t do in the coming months. I even daydream on the iPhone, idly calling up words and images when my concentration slips. Friends joke that I should get the iPhone implanted into my brain. But if Andy Clark is right, all this would do is speed up the processing, and free up my hands. The iPhone is part of my mind already. Clark is a connoisseur of the myriad ways in which the mind relies on the world to get its work done. The first part of this marvelous book explores some of these ways: the extension of our bodies, the extension of our senses, and crucially, the use of language as a tool to extend our thought. The second part of the book defends the thesis that in at least some of these cases, the world is not serving as a mere instrument for the mind. Rather, the relevant parts of the world have become parts of my mind. My iPhone is not my tool, or at least it is not wholly my tool. Parts of it have become parts of me. This is the thesis of the extended mind: when parts of the environment are coupled to the brain in the right way, they become parts of the mind. The thesis has a long history: I am told that there are hints of it in Dewey, Heidegger, and Wittgenstein. But no-one has done as much to give life to the idea as Andy Clark. In a series of important books and articles—Being There, Natural-Born Cyborgs, “Magic words: How language augments human computation”, and many others—he has explored the many ways in which the boundaries between mind and world are far more flexible than one might have thought.. (shrink)

Introduction: making the invisible visible -- The nobility of the material -- Research at war -- The guilded age of research -- The doctor as whistle-blower -- New rules for the laboratory -- Bedside ethics -- The doctor as stranger -- Life through death -- Commissioning ethics -- No one to trust -- New rules for the bedside -- Epilogue: The price of success.

One of the enduring concerns of moral philosophy is deciding who or what is deserving of ethical consideration. Much recent attention has been devoted to the "animal question" -- consideration of the moral status of nonhuman animals. In this book, David Gunkel takes up the "machine question": whether and to what extent intelligent and autonomous machines of our own making can be considered to have legitimate moral responsibilities and any legitimate claim to moral consideration. The machine question poses a (...) fundamental challenge to moral thinking, questioning the traditional philosophical conceptualization of technology as a tool or instrument to be used by human agents. Gunkel begins by addressing the question of machine moral agency: whether a machine might be considered a legitimate moral agent that could be held responsible for decisions and actions. He then approaches the machine question from the other side, considering whether a machine might be a moral patient due legitimate moral consideration. Finally, Gunkel considers some recent innovations in moral philosophy and critical theory that complicate the machine question, deconstructing the binary agent--patient opposition itself. Technological advances may prompt us to wonder if the science fiction of computers and robots whose actions affect their human companions could become science fact. Gunkel's argument promises to influence future considerations of ethics, ourselves, and the other entities who inhabit this world. (shrink)

Fechner's conception of psychophysics included both “outer psychophysics” the relation between stimulus intensity and the response reflecting sensation strength, and “inner psychophysics” the relation between neurelectric responses and sensation strength. In his own time outer psychophysics focussed on the form of the psychophysical law, with Fechner espousing a logarithmic law, Delboeuf a variant of the logarithmic law incorporating a resting level of neural activity, and Plateau a power law. One of the issues on which the dispute was focussed concerned the (...) appearance of contrasts if the overall illumination was increased or decreased; another issue was the question of whether a sensation of a “just noticeable difference” established for one value of a sensory dimension appeared the same for a value elsewhere on the dimension. The development of “inner psychophysics” led through the works of Delboeuf, Solomons, Jastrow, and Thurstone to modern signal detection theory. A third line of research, devoted to the question of what was meant by the “measurement” of sensation strength, stemmed from the criticism of Fechner's work by von Kries (1882) and others. Although a valid body of science could be built up without the intervening variable called “sensation strength,” such a science might be a cumbersome representation of reality. When an optical contrast is set up, and its overall illumination is increased or decreased, subjective contrasts involving medium levels of lightness vary little as illumination varies (as a power law based on sensation ratios or a logarithmic law based on sensation differences predict), but subjective contrasts involving extreme levels of lightness might be subject to the effects of other variables. (shrink)

David J. Kalupahana's Buddhist Philosophy: A Historical Analysis has, since its original publication in 1976, offered an unequaled introduction to the philosophical principles and historical development of Buddhism. Now, representing the culmination of Dr. Kalupahana's thirty years of scholarly research and reflection, A History of Buddhist Philosophy builds upon and surpasses that earlier work, providing a completely reconstructed, detailed analysis of both early and later Buddhism.

I reason: (1) For any x, if I knew that A contained x, then the odds are even that B contains either 2x or x/2, so the expected amount in B would be 5x/4. So (2) for all x, if I knew that A contained x, I would have an expected gain in switching to B. So (3) I should switch to B. But this seems clearly wrong, as my information about A and B is symmetrical.

An extensive literature has demonstrated that encoding information in a self-referential manner enhances subsequent memory performance. This ‘self-reference effect’ is generally elicited in paradigms that require participants to evaluate the self-descriptiveness of personality characteristics. Extending work of this kind, the current research explored the possibility that explicit evaluative processing is not a necessary precondition for the emergence of this effect. Rather, responses to self cues may enhance item encoding even in the absence of explicit evaluative instructions. We explored this hypothesis (...) by testing memory for items encoded in either an evaluative or relational context. The relational context was achieved by requesting participants to report the spatial relationship between target stimuli, and visual or verbal referent cues. The results revealed a self-referent memory advantage, regardless of the encoding context or triggering cue. The theoretical implications of these findings are considered. (shrink)

Bentham's dictum, ‘everybody to count for one, nobody for more than one’, is frequently noted but seldom discussed by commentators. Perhaps it is not thought contentious or exciting because interpreted as merely reminding the utilitarian legislator to make certain that each person's interests are included, that no one is missed, in working the felicific calculus. Since no interests are secure against the maximizing directive of the utility principle, which allows them to be overridden or sacrificed, the dictum is not usually (...) taken to be asserting fundamental rights that afford individuals normative protection against the actions of others or against legislative policies deemed socially expedient. Such non-conventional moral rights seem denied a place in a utilitarian theory so long as the maximization of aggregate happiness remains the ultimate standard and moral goal. (shrink)

Relationships between the behavioral integrity of managers as perceived by employees and employee attitudes (job satisfaction and life satisfaction), well-being (stress and health), and behaviors (absenteeism) were tested using data from the 2002 National Study of the Changing Workforce (n = 2,820). Using multivariate and univariate analysis, perceived behavioral integrity (PBI) was positively related to job and life satisfaction and negatively related to stress, poor health, and absenteeism. The effect size for the relationship with job satisfaction was medium-to-large while the (...) effect sizes with respect to the other variables were small-to-medium. There was no support for the hypotheses that women would perceive lower levels of behavioral integrity and that the strength of the relationships between PBI and the outcomes variables would be stronger among women than among men. (shrink)

This essay responds to the machine question in the affirmative, arguing that artifacts, like robots, AI, and other autonomous systems, can no longer be legitimately excluded from moral consideration. The demonstration of this thesis proceeds in four parts or movements. The first and second parts approach the subject by investigating the two constitutive components of the ethical relationship—moral agency and patiency. In the process, they each demonstrate failure. This occurs not because the machine is somehow unable to achieve what is (...) considered necessary and sufficient to be a moral agent or patient but because the characterization of agency and patiency already fail to accommodate others. The third and fourth parts respond to this problem by considering two recent alternatives—the all-encompassing ontocentric approach of Luciano Floridi’s information ethics and Emmanuel Levinas’s eccentric ethics of otherness. Both alternatives, despite considerable promise to reconfigure the scope of moral thinking by addressing previously excluded others, like the machine, also fail but for other reasons. Consequently, the essay concludes not by accommodating the alterity of the machine to the requirements of moral philosophy but by questioning the systemic limitations of moral reasoning, requiring not just an extension of rights to machines, but a thorough examination of the way moral standing has been configured in the first place. (shrink)

This is just a beginning categorization. I claim no 'objective correctness' for it. And of course the categories can be fluid, and the same joke can be a member of more than one category (and perhaps it will be funnier if it is). But thinking about the jokes which I can recall from the Humour Weekend, most seem to fall squarely into one or another category, indicating that perhaps this is a useful way of dividing jokes. It seems to me (...) that the "causes of humour" in all 4 classes are different, coming from different parts of the brain. (shrink)

ABSTRACTThe prohibition against the first use of force is defeasible, but under what conditions? Proponents of preventive war, both classical and contemporary, suggest that potential threats suffic...

What is involved in the meaning of our expressions? Frege suggested that there is an aspect of an expression.

When I say ‘Hesperus is Phosphorus’, I seem to express a proposition. And when I say ‘Joan believes that Hesperus is Phosphorus’, I seem to ascribe to Joan an attitude to the same proposition. But what are propositions? And what is involved in ascribing propositional attitudes?

This paper is the introduction to Function, Selection, and Design, consisting of the following sections: 1. Introduction 2. The Philosophical Problem 3. Recent Prehistory: The "State of the Art" in the 1960s 4. Wright and Cummins 5. Millikan 6. The Core Consensus and the Peripheral Disagreements 7. Unconclusion.

This paper describes issues associated with integrating the study of Ethical, Legal and Social Issues (ELSI) into ongoing scientific and technical research and describes an approach adopted by the authors for their own work with the center for nanophase materials sciences (CNMS) at the Oak Ridge national laboratory (ORNL). Four key questions are considered: (a) What is ELSI and how should it identify and address topics of interest for the CNMS? (b) What advantages accrue to incorporating ELSI into the CNMS? (...) (c) How should the integration of ELSI into the CNMS take place? (d) How should one judge the effectiveness of the activity? We conclude that ELSI research is not a monolithic body of knowledge, but should be adapted to the question at hand. Our approach focuses on junctures in the R&D continuum at which key decisions occur, avoids topics of a purely ethical nature or advocacy, and seeks to gather data in ways that permit testing the validity of generalization. Integrating ELSI into the CNMS allows dealing with topics firmly grounded in science, offers concrete examples of potential downstream applications and provides access to the scientists using the CNMS and their insights and observations. As well, integration provides the opportunity for R&D managers to benefit from ELSI insights and the potential to modify R&D agendas. Successful integration is dependent on the particular ELSI question set that drives the project. In this case questions sought to identify key choices, information of value to scientists, institutional attributes, key attributes of the CNMS culture, and alternatives for communicating results. The opportunity to consult with scientists on ELSI implications is offered, but not promoted. Finally, ELSI effectiveness is judged by observing the use to which research products are put within the CNMS, ORNL, and the community of external scholars. (shrink)

This offering in Routledge's acclaimed History of Philosophy series completes the acclaimed 10-volume collection. This work explores the schools of thought that developed in the wake of Platonism through the time of Augustine. The 11 separately authored in-depth articles include: Aristotle the scientist-- David Furley, Princeton University; Aristotle: logic and metaphysics-- Alan Code, Ohio State University; Aristotle: aesthetics and philosophy of mind -- David Gallop, Trent University, Ontario; Aristotle: ethics and politics-- Stephen White, University of Texas at Austin; (...) The peripatetic school-- Robert Sharples, University College, London; Hellenistic science and mathematics-- Alan C. Bowen, Institute for Research in Classical Philosophy and Science, New Jersey; Epicureanism-- Philip Mitsis, Cornell University; Stoicism-- Brad Inwood, University of Toronto; Ancient skepticism-- Michael Frede, Keble College, Oxford; Neo-Platonism-- Eyjdfur Kjalar Emilsson, University of Iceland; Augustine-- G.J.P. O'Daly, University College London. Order the entire Routledge History of Philosophy series and save 10% off each volume! (shrink)

Formulations of the essential commitment of the etiological theory of functions have varied significantly, with some individual authors' formulations even varying from one place to another. The logical geography of these various formulations is different from what is standardly assumed; for they are not stylistic variants of the same essential commitment, but stylistic variants of two non-equivalent versions of the etiological theory. I distinguish these “strong” and “weak” versions of the etiological theory (which differ with respect to the role of (...) selection in their definitions of function), draw out their respective implications, and argue that the weak version is to be preferred to the strong. (shrink)

Slavery has long stood as a mirror image to the conception of a free person in republican theory. This essay contends that slavery deserves this central status in a theory of freedom, but a more thorough examination of slavery in theory and in practice will reveal additional insights about freedom previously unacknowledged by republicans. Slavery combines imperium (state domination) and dominium (private domination) in a way that both destroys freedom today and diminishes opportunities to achieve freedom tomorrow. Dominium and imperium (...) working together are a greater affront to freedom than either working alone. However, an examination of slavery in practice, focusing on the experiences of American slaves, demonstrates that republicanisms’ acknowledged strategies for freedom-seeking, acquiring insulation from domination through law and through norms, do not encompass the full range of options. Slaves also seek freedom through physical absence, economic activity, and culture. The account of slavery and freedom developed here suggests republican accounts of freedom should either give up their focus on thresholds of freedom, or consider the possibility of a plural conception of freedom that extends beyond just freedom as non-domination to include freedom as collective world-making, or both. (shrink)